Homepage for Mouse Behavior Genetics (Koide's Lab)

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Mouse Genomics Resource Laboratory (MGRL)

Mouse Genomics Resource Laboratory (MGRL), National Institute of Genetics

Horii Y, Nagasawa T, Sakakibara H, Takahashi A, Tanave A, Matsumoto Y, Nagayama H, Yoshimi K, Yasuda MT, Shimoi K, Koide T.
Hierarchy in the home cage affects behaviour and gene expression in group-housed C57BL/6 male mice.
Scientific Reports 7: 6991, 2017. DOI:10.1038/s41598-017-07233-5

Matsumoto Y, Goto T, Nishino J, Nakaoka H, Tanave A, Takano-Shimizu T, Mott RF, Koide T.
Selective breeding and selection mapping using a novel wild-derived heterogeneous stock of mice revealed two closely-linked loci for tameness.
Scientific Reports 7: 4607, 2017. doi:10.1038/s41598-017-04869-1

Okabe S, Tsuneoka Y, Takahashi A, Oyama R, Watarai A, Maeda S, Honda Y, Nagasawa M, Mogi K, Nishimori K, Kuroda M, Koide T, Kikusui T. 
Pup exposure facilitates retrieving behavior via the oxytocin neural system in female mice.
Psychoneuroendocrinology 79: 20-30, 2017.

Yoshimi K, Kunihiro Y, Kaneko T, Nagahora H, Voigt B, Mashimo T. 
ssODN-mediated knock-in with CRISPR-Cas for large genomic regions in zygotes.
Nature Communications 7:10431, 2016. DOI:10.1038/ncomms10431

Hirata H, Takahashi A, Shimoda Y, Koide T.
Caspr3-deficient mice exhibit low motor learning during the early phase of the accelerated rotarod task.
PLoS ONE. 11(1):e0147887. 2016. doi: 10.1371/journal.pone.0147887.

Hirata H, Umemori J, Yoshioka H, Koide T, Watanabe K, Shimoda Y. 
Cell adhesion molecule Caspr3 is expressed in the mouse basal ganglia during early postnatal stages. 
Journal of Neuroscience Research
94(1):74-89, 2016. doi: 10.1002/jnr.23670.

Takahashi A, Sugimoto H, Kato S, Shiroishi T, Koide T.
Mapping of genetic factors that elicit intermale aggressive behavior on mouse chromosome 15: intruder effects and the complex genetic basis. 
PLoS ONE. 10(9):e0137764. 2015. doi: 10.1371/journal.pone.0137764.

Takahashi A, Lee RX, Iwasato T, Itohara S, Arima H, Bettler B, Miczek KA, Koide T. 
Glutamate input in the dorsal raphe nucleus as a determinant of escalated aggression in male mice. 
The Journal of Neuroscience
 22 April 2015, 35(16): 6452-6463, 2015. doi: 10.1523/JNEUROSCI.2450-14.2015

Takahashi A, Shiroishi T, Koide T. 
Genetic mapping of escalated aggression in wild-derived mouse strain MSM/Ms: association with serotonin-related genes. 
Frontiers in Neuroscience
 Volume8, Article156, 2014. doi: 10.3389/fnins.2014.00156

Kato S, Ishii A, Nishi A, Kuriki S, Koide T. 
Segregation of a QTL cluster for home-cage activity using a new mapping method based on regression analysis of congenic mouse strains. 
Heredity 
113, 416-423, 2014. doi: 10.1038/hdy.2014.42.

Arakawa T, Tanave A, Ikeuchi S, Takahashi A, Kakihara S, Kimura S, Sugimoto H, Asada N, Shiroishi T, Tomihara K, Tsuchiya T, Koide T
A male-specific QTL for social interaction behavior in mice mapped with automated pattern detection by a hidden Markov model incorporated into newly developed freeware.
Journal of Neuroscience Methods 234, 127-134, 2014.  doi:10.1016/j.jneumeth.2014.04.012.

Takahashi A, Nagayasu K, Nishitani N, Kaneko S, Koide T. 
Control of intermale aggression by the medial prefrontal cortex activation in the mouse. 
PLoS ONE
 9(4): e94657, 2014. doi:10.1371/journal.pone.0094657.

Kanno K., Kokubo H., Takahashi A., Koide T., Ishiura S. 
Enhanced prepulse inhibition and low sensitivity to a dopamine agonist in Hesr1-knockout mice. 
Journal of Neuroscience Research
 92: 287-297, 2014. doi: 10.1002/jnr.23291.

Goto T., Tanave A., Moriwaki K., Shiroishi T., Koide T. 
Selection for reluctance to avoid humans during the domestication of mice. 
Genes, Brain, and Behavior
 12: 760-770, 2013. doi: 10.1111/gbb.12088 PubMed

Umemori J, Mori A, Ichiyanagi K, Uno T, Koide T. 
Identification of both copy number variation-type and constant-type core elements in a large segmental duplication region of the mouse genome. 
BMC Genomics
 14: 455, 2013. doi: 10.1186/1471-2164-14-455.

Koide T., Goto, T., Takano-Shimizu, T. 
Genomic mixing to elucidate the genetic system of complex traits. 
Experimental Animals
 61: 503-509, 2012. http://doi.org/10.1538/expanim.61.503.

Takahashi A., Schilit A. N., Kim J., Debold J. F., Koide T., Miczek K. A. 
Behavioral characterization of escalated aggression induced by GABA(B) receptor activation in the dorsal raphe nucleus. 
Psychopharmacology
 224: 155-156, 2012.

Sugimoto H., Okabe S., Kato M., Koshida N., Shiroishi T., Mogi K., Kikusui T., Koide T. 
A role for strain differences in waveforms of ultrasonic vocalizations during male–female interaction.
PLoS ONE 6: e22093, 2011. PubMed

Ishii A., Koide T., Takahashi A., Shiroishi T., Hettinger T.P., Frank M.E., Savoy L.D., Formaker B.K., Yertutanol S., Lionikas A. and Blizard D.A. 
B6-MSM consomic mouse strains reveal multiple loci for genetic variation in sucrose octaacetate aversion. 
Behavior Genetics
 41: 716-723, 2011. PubMed

Koide T., Ikeda K., Ogasawara M., Shiroishi T., Moriwaki K., and Takahashi A. 
A new twist on behavioral genetics by incorporating wild-derived mouse strains. 
Experimental Animals
 60: 347-354, 2011. PubMed

Nishi A., Ishii A., Takahashi A., Shiroishi T., Koide T. 
QTL analysis of measures of mouse home-cage activity using B6/MSM consomic strains. 
Mammalian Genome
 21: 477-485, 2010. PubMed PDF (Open access)

Takahashi, A., Tomihara, K., Shiroishi, T., Koide, T. 
Genetic mapping of social interaction behavior in B6/MSM consomic mouse strains. 
Behavior Genetics
 40: 366-376, 2010. PubMed PDF (Open access)

Tanaka, N., Waki, K., Kaneda, H., Suzuki, T., Yamada, I., Furuse, T, Kobayashi, K., Motegi, H., Toki, H., Inoue, M., Minowa, O., Noda, N., Takao, K., Miyakawa, T., Takahashi, A., Koide, T., Wakana, S., Masuya, H.
SDOP-DB: A comparative standardised-protocol database for mouse phenotypic analyses. 
Bioinformatics
 26(8): 1133-1134, 2010.

Dowse, H., Umemori, J., Koide, T. 
Ultradian Components in the Locomotor Activity Rhythms of the Genetically Normal Mouse, Mus musculus. 
The Journal of Experimental Biology 
213: 1788-1795, 2010. PubMed

Kubota T, Miyake K, Hirasawa T, Nagai K, Koide T. 
Novel etiological and threrapeutic strategies for neurodiseases: Epigenetic understanding of gene-environment interactions. 
J Pharmacol Sci
 113: 3-8, 2010.

Umemori, J., Nishi, A., Lionikas, A., Sakaguchi, T., Kuriki, S., Blizard, D.A. and Koide, T. 
QTL analyses of temporal and intensity components of home-cage activity in KJR and C57BL/6J strains. 
BMC Genetics
 10: 40, 2009. PubMed Open Access

Takahashi, A.; Nishi, A., Ishii, A., Shiroishi, T., Koide, T. 
Systematic analysis of emotionality in consomic mouse strains established from C57BL/6J and wild-derived MSM/Ms. 
Genes, Brain and Behavior
 7: 849-858, 2008. PubMed PDF

Takahashi, A., Shiroishi, T., Koide, T. 
Multigenic factors associated with a hydrocephalus-like phenotype found in inter-subspecific consomic mouse strains. 
Mammalian Genome
 29: 333-338, 2008. PubMed

Shigeta, Y., Kasai, S., Han, W., Hata, H., Nishi, A., Takamatsu, Y., Hagino, Y., Yamamoto, H., Koide, T., Shiroishi, T., Kasai, K., Tsunashima, K., Kato, N. and Ikeda, K.
Association of morphine-induced antinociception with variations in the 5' flanking and 3' untranslated regions of the μ opioid receptor gene in 10 inbred mouse strains.
Pharmacogenet. Genomics 18: 927-936, 2008.

Liu, Y.-H., Takahashi, A., Kitano, T., Koide, T., Shiroishi, T., Moriwaki, K., and Saitou, N. 
Mosaic genealogy of the Mus musculus genome revealed by 21 nuclear genes from its three subspecies. 
Genes and Genetic Systems
 83(1): 77-88, 2008.

Blizard, D. A., Takahashi, A., Galsworthy, M., Martin, B., Koide, T. 
Test standardization in behavioral neuroscience: a response to Stanford. 
Journal of Psychopharmacology
 21(2): 136-139, 2007.

Takahashi, A., Kato, K., Makino, J., Shiroishi, T., Koide, T. 
Multivariate analysis of temporal descriptions of open-field behavior in wild derived mouse strains.
Behavior Genetics 36: 763-774, 2006.

Ogasawara, M., Imanishi, T., Moriwaki, K., Gaudieri, S., Tsuda, H., Hashimoto, H., Shiroishi, T., Gojobori, T., Koide, T. 
Length variation of CAG/CAA triplet repeats in 50 genes among 16 inbred mouse strains.
Gene 349: 107-119, 2005.

Esumi, S., Kakazu, N., Taguchi, Y., Hirayama, T., Sasaki, A., Hirabayashi, T., Koide, T., Kitsukawa, T., Hamada, S., Yagi, T.
Monoallelic yet combinatorial expression of variable exons of the protocadherin-a gene cluster in single neurons.
Nature Genetics 37: 171-176, 2005.

Taguchi, Y., Koide, T., Shiroishi, T., Yagi, T. 
Molecular evolution of Cadherin-related neuronal receptor/protocadherin α (CNR/Pcdhα) gene cluster in Mus musculus subspecies.
Mol. Biol. Evol. 22: 1433-1443, 2005.

Koide, T.
Genetic analysis of spontaneous activity using wild derived mouse strains.
The Japanese Journal of Animal Psychology 54: 59-66, 2004.

Furuse, T., Miura, Y., Yagasaki, K., Shiroishi, T., Koide, T.
Identification of QTLs for differential capsaicin sensitivity between mouse strains KJR and C57BL/6.
Pain 105: 169-175, 2003.




Mammalian Genetics Laboratory, National Institute of Genetics
 

Isobe, T., Yoshino, M., Mizuno, K., Fisher Lindahl, K., Koide, T., Gaudiery, S., Gojobori, T., Shiroishi, T.
Molecular characterization of the Pb recombination hotspot in the mouse major histocompatibility complex class I region.
Genomics 80: 229-235, 2002.

Chan, B. W. H., Chan, K.-S., Koide, T., Yeung, S.-M., Leung, M. B. W., Copp, A. J., Loeken, M. R., Shiroishi, T., Shum, A. S. W.
Maternal Diabetes Increases the Risk of Caudal Regression Caused by Retinoic Acid.
Diabetes 51: 2811-2816, 2002.

Furuse, T., Takano-Shimizu, T., Moriwaki, K., Shiroishi, T., Koide, T.
QTL analyses of spontaneous locomotor activity using mouse strains from Mishima battery.
Mammalian Genome 13: 411-415, 2002.

Furuse, T., Blizard, D. A., Moriwaki, K., Miura, Y., Yagasaki, K., Shiroishi, T., Koide, T.
Genetic diversity underlying capsaicin intake in the Mishima battery of mouse strains.
Brain Research Bulletin 57: 49-55, 2002.

Watanabe, T., Yoshimura, A., Mishima, Y., Endo, Y., Shiroishi, T., Koide, T., Sasaki, H., Asakura, H., Kominami, R.
Differential chromatin packaging of genomic imprinted regions between expressed and non-expressed alleles.
Human Molecular Genetics 9: 3029-3035, 2000.

Koide, T., Moriwaki, K., Ikeda, K., Niki, H. and Shiroishi, T.
Multi-phenotype behavioral characterization of inbred strains derived from wild stocks of Mus musculus.
Mammalian Genome 11: 664-670, 2000.

Shum, A. S. W., Poon, L. L. M., Tang, W. W. T., Koide, T., Chan, B. W. H., Leung, Y-C. G., Shiroishi, T. and Coop, A. J.
Retinoic acid induces down regulation of Wnt-3a, apoptosis and diversion of tail bud cells to a neural fate in the mouse embryo.
Mechanisms of Development 84: 17-30, 1999.

Sato, H., Koide, T., Sagai, T. Ishiguro, S., Tamai, M., Saitou, N., Shiroishi, T.
The genomic organization of type I keratin genes in mice.
Genomics 56: 303-309, 1999.

Koide, T., Moriwaki, K., Uchida, K., Mita, A., Sagai, T., Yonekawa, H., Katoh, H., Miyashita, N., Tsuchiya, K., Nielsen, T. J. and Shiroishi, T.
A new inbred strain JF1 established from Japanese fancy mouse carrying the classic piebald allele.
Mammalian Genome 9: 15-19, 1998.

Sato, H., Koide, T., Masuya, H., Wakana, S., Sagai, T., Ishiguro, S., Tamai, M. and Shiroishi, T.
A new mutation Rim3 resembling Reden is mapped close to retinoic acid receptor alpha (Rara) gene on mouse Chromosome 11.
Mammalian Genome 9: 20-25, 1998.

Sagai, T., Koide, T., Endo, M., Tanoue, K., Kikkawa, H., Yonekawa, H., Ishiguro, S., Tamai, S., Matsuda, Y., Wakana, S. and Shiroishi, T.
rim2 (recombination induced mutation 2) is a new allele of pearl and a mouse model of human Hermansky-Pudlak Syndrome (HPS): genetic and physical mapping.
Mammalian Genome 9: 2-7, 1998.

Obata, Y., Kaneko-Ishino, T., Koide, T., Takai, Y., Ueda, T., Domeki, I., Shiroishi, T., Ishino, F. and Kono, T.
Disruption of primary imprinting during oocyte growth leads to the modified expression of imprinted genes during embryogenesis.
Development 125: 1553-1560, 1998. 



University of Cambridge, Wellcome/CRC Institute, Prof Azim Surani's lab
 

Ainscough, J. F-X., Koide, T., Tada, M., Barton, S., and Surani, M. A.
Imprinting of Igf2 and H19 from a 130kb YAC transgene.
Development 124: 3621-3632, 1997.

Koide, T., Ainscough, J.,Wijgerde, M. and Surani, M. A.
Comparative analysis of Igf-2/H19 imprinted domain: identification of a highly conserved intergenic DNase I hypersensitive region.
Genomics 24: 1-8, 1994.



National Institute of Genetics, JSPS Postdoctoral fellow
 

Mizuno, K., Koide, T., Sagai, T., Moriwaki, K. and Shiroishi, T.
Molecular analysis of a recombinational hotspot adjacent to Lmp2 gene in the mouse MHC: fine location and chromatin structure.
Mammalian Genome 7, 490-496, 1996 

Shiroishi, T., Koide, T., Yoshino, M., Sagai, T. and Moriwaki, K.
Hotspots of homologous recombination in mouse meiosis.
Adv. Biophys. 31, 63-76, 1994.

Koide, T., Yoshino, M., Niwa, M., Ishiura, M., Shiroishi, T. and Moriwaki, K.
The amplified long genomic sequence (ALGS) located in the centromeric regions of mouse chromosomes.
Genomics 13, 1186-1191, 1992.



Osaka Univerisity (National Institute of Basic Biology)

Koide, T., Ishiura, M., Hazumi, N., Shiroishi, T., Okada, Y. and Uchida, T.
Amplification of a long sequence that includes a processed pseudogene for elongation factor 2 in the mouse.
Genomics 6, 80-88, 1990.

Koide, T., Ishiura, M., Iwai, K., Inoue, M., Kaneda, Y., Okada, Y. and Uchida, T.
A case of Fabry's disease in a patient with no a-galactosidase A activity caused by a single amino acid substitution of Pro-40 by Ser.
FEBS Letters 259, 353-356, 1990.

Ishiura, M., Hazumi, N., Koide, T., Uchida, T. and Okada, Y.

recB recC sbcB recJ host prevents recA-independent deletions in recombinant cosmid DNA propagated in Escherichia coli. 
Journal of Bacteriology
 171, 1068-1074, 1989.

National Institute of Genetics    | | ©2005 Tsuyoshi Koide    Last update 2016 April